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Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways applying Petri net formalism and in silico knockout analysis

The paper describes a mathematical model of the molecular switches of cell survival, apoptosis, and necroptosis in cellular signaling pathways initiated by tumor necrosis factor 1. Based on experimental findings in the literature, we constructed a Petri net model based on detailed molecular reaction...

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Detalles Bibliográficos
Autores principales: Amstein, Leonie K., Ackermann, Jörg, Hannig, Jennifer, Đikić, Ivan, Fulda, Simone, Koch, Ina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467317/
https://www.ncbi.nlm.nih.gov/pubmed/35994517
http://dx.doi.org/10.1371/journal.pcbi.1010383