Combination of ligand and structure based virtual screening approaches for the discovery of potential PARP1 inhibitors

Poly (ADP-ribose) polymerase 1 (PARP1) has high therapeutic value as biomolecular target for research and development of small molecules with antineoplastic activity, since it is upregulated in many cancers, especially in ovarian and BRCA 1/2 mutated breast cancers. Decades of investigation of PARP...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Sanea, Mohammad M., Chilingaryan, Garri, Abelyan, Narek, Mamikonyan, Michael, Gasparyan, Hayk, Hovhannisyan, Sargis, Hamdi, Abdelrahman, Ali, Ahmed R., Selim, Samy, Mohamed, Ahmed A. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467328/
https://www.ncbi.nlm.nih.gov/pubmed/36094927
http://dx.doi.org/10.1371/journal.pone.0272065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467328/
https://www.ncbi.nlm.nih.gov/pubmed/36094927
http://dx.doi.org/10.1371/journal.pone.0272065

Ejemplares similares