A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE)

The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition was employed to connect a 1-deoxynojirimycin moiety with a benzotriazole scaffold is reported. The heterodimers were investigated as inhibitors against acetylcholinesterase (AChE) and butyrylcholinesterase...

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Detalles Bibliográficos
Autores principales: Evangelista, Tereza Cristina Santos, López, Óscar, Puerta, Adrián, Fernandes, Miguel X., Ferreira, Sabrina Baptista, Padrón, José M., Fernández-Bolaños, José G., Sydnes, Magne O., Lindbäck, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467581/
https://www.ncbi.nlm.nih.gov/pubmed/36065944
http://dx.doi.org/10.1080/14756366.2022.2117912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467581/
https://www.ncbi.nlm.nih.gov/pubmed/36065944
http://dx.doi.org/10.1080/14756366.2022.2117912

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