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Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities
The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) are involved in metabolic processes, such as de novo lipogenesis and fatty acid biosynthesis. We review the drug design landscape for obtaining CA VA/VB-selective/effective inhibitors, starting from the clinical ob...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467601/ https://www.ncbi.nlm.nih.gov/pubmed/36073149 http://dx.doi.org/10.1080/14756366.2022.2121393 |