Extracellular 5′-methylthioadenosine inhibits intracellular symmetric dimethylarginine protein methylation of FUSE-binding proteins

Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway that converts the polyamine synthesis byproduct 5′-deoxy-5′-methylthioadenosine (MTA) into methionine. Inactivation of MTAP, often by homozygous deletion, is found in both solid and hematologic malignancies an...

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Detalles Bibliográficos
Autores principales: Tang, Baiqing, Lee, Hyung-Ok, Gupta, Sapna, Wang, Liqun, Kurimchak, Alison M., Duncan, James S., Kruger, Warren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467882/
https://www.ncbi.nlm.nih.gov/pubmed/35963436
http://dx.doi.org/10.1016/j.jbc.2022.102367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467882/
https://www.ncbi.nlm.nih.gov/pubmed/35963436
http://dx.doi.org/10.1016/j.jbc.2022.102367

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