Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation

Finely tuned mitogen-activated protein kinase (MAPK) signaling is important for cancer cell survival. Perturbations that push cells out of the MAPK fitness zone result in cell death. Previously, in a screen of the North China Pharmaceutical Group Corporation’s pure compound library of microbial orig...

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Detalles Bibliográficos
Autores principales: Li, Guan-Nan, Zhao, Xue-Jiao, Wang, Zhen, Luo, Meng-Shi, Shi, Shen-Nan, Yan, Dan-Mei, Li, Hua-Yi, Liu, Jia-Hao, Yang, Yang, Tan, Jia-Hong, Zhang, Ze-Yu, Chen, Ru-Qi, Lai, Hui-Ling, Huang, Xiao-Yuan, Zhou, Jian-Feng, Ma, Ding, Fang, Yong, Gao, Qing-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468165/
https://www.ncbi.nlm.nih.gov/pubmed/36097006
http://dx.doi.org/10.1038/s41392-022-01131-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468165/
https://www.ncbi.nlm.nih.gov/pubmed/36097006
http://dx.doi.org/10.1038/s41392-022-01131-7

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