GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway

The mannose-6-phosphate (M6P) biosynthetic pathway for lysosome biogenesis has been studied for decades and is considered a well-understood topic. However, whether this pathway is regulated remains an open question. In a genome-wide CRISPR/Cas9 knockout screen, we discover TMEM251 as the first regul...

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Detalles Bibliográficos
Autores principales: Zhang, Weichao, Yang, Xi, Li, Yingxiang, Yu, Linchen, Zhang, Bokai, Zhang, Jianchao, Cho, Woo Jung, Venkatarangan, Varsha, Chen, Liang, Burugula, Bala Bharathi, Bui, Sarah, Wang, Yanzhuang, Duan, Cunming, Kitzman, Jacob O., Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468337/
https://www.ncbi.nlm.nih.gov/pubmed/36096887
http://dx.doi.org/10.1038/s41467-022-33025-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468337/
https://www.ncbi.nlm.nih.gov/pubmed/36096887
http://dx.doi.org/10.1038/s41467-022-33025-1

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