Cargando…

GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway

The mannose-6-phosphate (M6P) biosynthetic pathway for lysosome biogenesis has been studied for decades and is considered a well-understood topic. However, whether this pathway is regulated remains an open question. In a genome-wide CRISPR/Cas9 knockout screen, we discover TMEM251 as the first regul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Weichao, Yang, Xi, Li, Yingxiang, Yu, Linchen, Zhang, Bokai, Zhang, Jianchao, Cho, Woo Jung, Venkatarangan, Varsha, Chen, Liang, Burugula, Bala Bharathi, Bui, Sarah, Wang, Yanzhuang, Duan, Cunming, Kitzman, Jacob O., Li, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468337/ https://www.ncbi.nlm.nih.gov/pubmed/36096887 http://dx.doi.org/10.1038/s41467-022-33025-1

Ejemplares similares

A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation
por: Zhang, Weichao, et al.
Publicado: (2021)

ER-associated degradation in cystinosis pathogenesis and the prospects of precision medicine
por: Venkatarangan, Varsha, et al.
Publicado: (2023)

High-Throughput Splicing Assays Identify Known and Novel WT1 Exon 9 Variants in Nephrotic Syndrome
por: Smith, Cathy, et al.
Publicado: (2023)

Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk
por: Jia, Xiaoyan, et al.
Publicado: (2021)

Novel Photosensitizer β-Mannose-Conjugated Chlorin e6 as a Potent Anticancer Agent for Human Glioblastoma U251 Cells
por: Shinoda, Yo, et al.
Publicado: (2020)

Analysis of mannosidase I activity in interphase and mitotic cells by lectin staining and endoglycosidase H treatment
por: Li, Jie, et al.
Publicado: (2023)

The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis
por: Lorenzi, Isotta, et al.
Publicado: (2018)

The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis
por: Kang, Peter B., et al.
Publicado: (2005)

Tmem138 is localized to the connecting cilium essential for rhodopsin localization and outer segment biogenesis
por: Guo, Dianlei, et al.
Publicado: (2022)

Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules
por: Parchure, Anup, et al.
Publicado: (2022)

Effect of Corilagin on the Proliferation and NF-κB in U251 Glioblastoma Cells and U251 Glioblastoma Stem-Like Cells
por: Yang, Wen-Tao, et al.
Publicado: (2016)

Health Tract, No. 251: Trichiniasis
Publicado: (1866)

Hydrogen peroxide induces Arl1 degradation and impairs Golgi-mediated trafficking
por: Ireland, Stephen C., et al.
Publicado: (2020)

TMEM139 prevents NSCLC metastasis by inhibiting lysosomal degradation of E‐cadherin
por: Zhang, Shuai, et al.
Publicado: (2022)

Lysosomal dysfunction in TMEM106B hypomyelinating leukodystrophy
por: Ito, Yoko, et al.
Publicado: (2018)

Subject index volumes 251–350
Publicado: (1988)

Synchronized proinsulin trafficking reveals delayed Golgi export accompanies β-cell secretory dysfunction in rodent models of hyperglycemia
por: Boyer, Cierra K., et al.
Publicado: (2023)

GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin
por: Ahat, Erpan, et al.
Publicado: (2022)

Heart failure with preserved ejection fraction: New approaches to diagnosis and management
por: Upadhya, Bharathi, et al.
Publicado: (2019)

Combination of Helicobacter pylori infection and the interleukin 8 –251 T > A polymorphism, but not the mannose-binding lectin 2 codon 54 G > A polymorphism, might be a risk factor of gastric cancer
por: Chang, Young Woon, et al.
Publicado: (2017)

Functional characterization of the lysosomal membrane protein TMEM192 in mice
por: Nguyen, Thuy Linh, et al.
Publicado: (2017)

Gating and selectivity mechanisms for the lysosomal K(+) channel TMEM175
por: Oh, SeCheol, et al.
Publicado: (2020)

Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175
por: Oh, SeCheol, et al.
Publicado: (2022)

SARS-CoV-2 triggers Golgi fragmentation via down-regulation of GRASP55 to facilitate viral trafficking
por: Zhang, Jianchao, et al.
Publicado: (2022)

TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion
por: Zhang, Mengling, et al.
Publicado: (2020)

Lysosome biogenesis: Regulation and functions
por: Yang, Chonglin, et al.
Publicado: (2021)

Cytosolic Ca(2+) Modulates Golgi Structure Through PKCα-Mediated GRASP55 Phosphorylation
por: Ireland, Stephen, et al.
Publicado: (2020)

Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells
por: Zhang, Zhen, et al.
Publicado: (2016)

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice
por: Feng, Tuancheng, et al.
Publicado: (2020)

Suppression of chloride voltage-gated channel 3 expression increases sensitivity of human glioma U251 cells to cisplatin through lysosomal dysfunction
por: Zhang, Yihe, et al.
Publicado: (2018)

Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase
por: Gorelik, Alexei, et al.
Publicado: (2022)

Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions
por: Otomo, Takanobu, et al.
Publicado: (2015)

Pain During a Marathon Run: Prevalence and Correlates in a Cross-Sectional Study of 1,251 Recreational Runners in 251 Marathons
por: O'Connor, Patrick J.
Publicado: (2021)

B7-H4 expression is elevated in human U251 glioma stem-like cells and is inducible in monocytes cultured with U251 stem-like cell conditioned medium
por: Mo, Lian-Jie, et al.
Publicado: (2013)

Cryo-EM structures of human TMEM120A and TMEM120B
por: Ke, Meng, et al.
Publicado: (2021)

Lysosomal TMEM9‐LAMTOR4‐controlled mTOR signaling integrity is required for mammary tumorigenesis
por: Zhang, Shengzhe, et al.
Publicado: (2022)

Identification of U251 glioma stem cells and their heterogeneous stem-like phenotypes
por: ZHANG, SUOJUN, et al.
Publicado: (2013)

Effect of temozolomide on livin and caspase-3 in U251 glioma stem cells
por: LI, GENHUA, et al.
Publicado: (2015)

Pharmacokinetic analysis of new synthetic antimalarial N-251
por: Okada, Kazuaki, et al.
Publicado: (2019)

Index to Hydrobiologia Volumes 251-384 (1993-1999)
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_pm7q97t1mtbuaahthhofpor395