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Concentration-dependent thermodynamic analysis of the partition process of small ligands into proteins

In the category of functional low-affinity interactions, small ligands may interact with multiple protein sites in a highly degenerate manner. Better conceived as a partition phenomenon at the molecular interface of proteins, such low-affinity interactions appear to be hidden to our current experime...

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Detalles Bibliográficos
Autores principales: Cirqueira, Leonardo, Stock, Letícia, Treptow, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468351/
https://www.ncbi.nlm.nih.gov/pubmed/36147679
http://dx.doi.org/10.1016/j.csbj.2022.08.049