Two types of human TCR differentially regulate reactivity to self and non-self antigens

Based on analyses of TCR sequences from over 1,000 individuals, we report that the TCR repertoire is composed of two ontogenically and functionally distinct types of TCRs. Their production is regulated by variations in thymic output and terminal deoxynucleotidyl transferase (TDT) activity. Neonatal...

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Detalles Bibliográficos
Autores principales: Trofimov, Assya, Brouillard, Philippe, Larouche, Jean-David, Séguin, Jonathan, Laverdure, Jean-Philippe, Brasey, Ann, Ehx, Gregory, Roy, Denis-Claude, Busque, Lambert, Lachance, Silvy, Lemieux, Sébastien, Perreault, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468382/
https://www.ncbi.nlm.nih.gov/pubmed/36111255
http://dx.doi.org/10.1016/j.isci.2022.104968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468382/
https://www.ncbi.nlm.nih.gov/pubmed/36111255
http://dx.doi.org/10.1016/j.isci.2022.104968

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