CDK12 regulates co-transcriptional splicing and RNA turnover in human cells

The cyclin-dependent kinase CDK12 has garnered interest as a cancer therapeutic target as DNA damage response genes are particularly suppressed by loss of CDK12 activity. In this study, we assessed the acute effects of CDK12 inhibition on transcription and RNA processing using nascent RNA Bru-seq an...

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Detalles Bibliográficos
Autores principales: Magnuson, Brian, Bedi, Karan, Narayanan, Ishwarya Venkata, Bartkowiak, Bartlomiej, Blinkiewicz, Hailey, Paulsen, Michelle T., Greenleaf, Arno, Ljungman, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468413/
https://www.ncbi.nlm.nih.gov/pubmed/36111258
http://dx.doi.org/10.1016/j.isci.2022.105030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468413/
https://www.ncbi.nlm.nih.gov/pubmed/36111258
http://dx.doi.org/10.1016/j.isci.2022.105030

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