Cargando…

Inflammation aggravated the hepatotoxicity of triptolide by oxidative stress, lipid metabolism disorder, autophagy, and apoptosis in zebrafish

Triptolide is a major compound isolated from the Tripterygium wilfordii Hook that is mainly used for the treatment of autoimmune disorders and inflammatory diseases. Though triptolide-induced hepatotoxicity has been widely reported, the hepatic effects when the patients are in an inflammatory state...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Chenqinyao, Zhang, Changqing, Zhu, Chengyue, Zhang, Jie, Xia, Qing, Liu, Kechun, Zhang, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468416/ https://www.ncbi.nlm.nih.gov/pubmed/36110530 http://dx.doi.org/10.3389/fphar.2022.949312

Ejemplares similares

The molecular pathogenesis of triptolide-induced hepatotoxicity
por: Hu, Yeqing, et al.
Publicado: (2022)

Macrophage malfunction in Triptolide-induced indirect hepatotoxicity
por: Qin, Tingting, et al.
Publicado: (2022)

Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats
por: Yang, Jing, et al.
Publicado: (2017)

Psoralen Induces Developmental Toxicity in Zebrafish Embryos/Larvae Through Oxidative Stress, Apoptosis, and Energy Metabolism Disorder
por: Xia, Qing, et al.
Publicado: (2018)

Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats
por: Zhang, Kai-Kai, et al.
Publicado: (2021)

Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters
por: Hou, Zhenyan, et al.
Publicado: (2018)

Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model
por: Vliegenthart, Adriaan D. Bastiaan, et al.
Publicado: (2017)

Triptolide Induces Leydig Cell Apoptosis by Disrupting Mitochondrial Dynamics in Rats
por: Lv, Linyan, et al.
Publicado: (2021)

Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos
por: Xia, Qing, et al.
Publicado: (2021)

Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway
por: Zhang, Linluo, et al.
Publicado: (2022)

Xiaoaiping Induces Developmental Toxicity in Zebrafish Embryos Through Activation of ER Stress, Apoptosis and the Wnt Pathway
por: Li, Juanjuan, et al.
Publicado: (2018)

Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma
por: Wang, Geng, et al.
Publicado: (2023)

Evaluation of the Developmental Toxicity Induced by E804 in Zebrafish Embryos
por: Wang, Rongchun, et al.
Publicado: (2020)

Therapeutic Potential of Triptolide in Treating Bone-Related Disorders
por: Gang, Wu, et al.
Publicado: (2022)

Triptolide Induces Apoptosis Through Fas Death and Mitochondrial Pathways in HepaRG Cell Line
por: You, Longtai, et al.
Publicado: (2018)

Sex-Related Differences of Lipid Metabolism Induced by Triptolide: The Possible Role of the LXRα/SREBP-1 Signaling Pathway
por: Jiang, Zhenzhou, et al.
Publicado: (2016)

The therapeutic potential of triptolide and celastrol in neurological diseases
por: Cui, Yueran, et al.
Publicado: (2022)

Activation of Nrf2 Protects against Triptolide-Induced Hepatotoxicity
por: Li, Jia, et al.
Publicado: (2014)

Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats
por: Wang, Lan, et al.
Publicado: (2018)

GLT25D2 Is Critical for Inflammatory Immune Response to Promote Acetaminophen-Induced Hepatotoxicity by Autophagy Pathway
por: Zhang, Xiaohui, et al.
Publicado: (2020)

Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress
por: Zhong, Yadi, et al.
Publicado: (2022)

Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway
por: Zhou, Yuyan, et al.
Publicado: (2020)

Effect of Adoptive Transfer or Depletion of Regulatory T Cells on Triptolide-induced Liver Injury
por: Wang, Xinzhi, et al.
Publicado: (2016)

Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes
por: Lu, Yan, et al.
Publicado: (2017)

Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis
por: Guo, Zhaojuan, et al.
Publicado: (2021)

Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review
por: Fu, Ze, et al.
Publicado: (2023)

Ultrasound Guided Intra-Articular Injection of Triptolide-loaded Solid Lipid Nanoparticle for Treatment of Antigen-Induced Arthritis in Rabbits
por: Li, Shilin, et al.
Publicado: (2022)

Effect of Triptolide on Temporal Expression of Cell Cycle Regulators During Cardiac Hypertrophy
por: Li, Jing-Mei, et al.
Publicado: (2020)

Protective Effect of 18β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats
por: Yang, Guanghua, et al.
Publicado: (2017)

Effect of the Natural Product Triptolide on Pancreatic Cancer: A Systematic Review of Preclinical Studies
por: Zhang, Chi, et al.
Publicado: (2017)

Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia
por: Yang, Yang, et al.
Publicado: (2015)

Potential Target Analysis of Triptolide Based on Transcriptome-Wide m(6)A Methylome in Rheumatoid Arthritis
por: Fan, Danping, et al.
Publicado: (2022)

(1)H NMR-Based Metabolomics Reveals the Antitumor Mechanisms of Triptolide in BALB/c Mice Bearing CT26 Tumors
por: Li, Cheng, et al.
Publicado: (2019)

Hepatotoxic potential of asarones: in vitro evaluation of hepatotoxicity and quantitative determination in herbal products
por: Patel, Dhavalkumar N., et al.
Publicado: (2015)

Effect of Triptolide on Dextran Sodium Sulfate-Induced Ulcerative Colitis and Gut Microbiota in Mice
por: Wu, Hao, et al.
Publicado: (2020)

Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review
por: Yuan, Kai, et al.
Publicado: (2019)

The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy
por: Yan, Min, et al.
Publicado: (2022)

In vivo protective effects of chlorogenic acid against triptolide-induced hepatotoxicity and its mechanism
por: Wang, Jun-Ming, et al.
Publicado: (2018)

Lipidomic Profiling Reveals Disruption of Lipid Metabolism in Valproic Acid-Induced Hepatotoxicity
por: Xu, Shansen, et al.
Publicado: (2019)

Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway
por: Guo, Lin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gerh81kl9ua7f7m81e5p5imk95