Pharmacokinetics, safety, and tolerability of gepotidacin administered as single or repeat ascending doses, in healthy adults and elderly subjects

Gepotidacin, a novel, first‐in‐class triazaacenaphthylene antibiotic, inhibits bacterial DNA replication by a distinct mechanism of action. We report the pharmacokinetics (PKs), safety, and tolerability of gepotidacin following single or multiple ascending doses. Studies 1 and 2 were randomized, sin...

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Detalles Bibliográficos
Autores principales: Tiffany, Courtney, Dumont, Etienne F., Hossain, Mohammad, Srinivasan, Meenakshi, Swift, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468557/
https://www.ncbi.nlm.nih.gov/pubmed/35769034
http://dx.doi.org/10.1111/cts.13359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468557/
https://www.ncbi.nlm.nih.gov/pubmed/35769034
http://dx.doi.org/10.1111/cts.13359

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