α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes

Cell–matrix adhesions are mainly provided by integrin-mediated focal adhesions (FAs). We previously found that Shp2 is essential for FA maturation by promoting ROCK2 activation at FAs. In this study, we further delineated the role of α-actinin-4 in the FA recruitment and activation of Shp2. We used...

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Detalles Bibliográficos
Autores principales: Tseng, Chien-Chun, Zheng, Ru-Hsuan, Lin, Ting-Wei, Chou, Chih-Chiang, Shih, Yu-Chia, Liang, Shao-Wei, Lee, Hsiao-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468603/
https://www.ncbi.nlm.nih.gov/pubmed/36096674
http://dx.doi.org/10.26508/lsa.202201557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468603/
https://www.ncbi.nlm.nih.gov/pubmed/36096674
http://dx.doi.org/10.26508/lsa.202201557

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