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α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes
Cell–matrix adhesions are mainly provided by integrin-mediated focal adhesions (FAs). We previously found that Shp2 is essential for FA maturation by promoting ROCK2 activation at FAs. In this study, we further delineated the role of α-actinin-4 in the FA recruitment and activation of Shp2. We used...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Life Science Alliance LLC
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468603/ https://www.ncbi.nlm.nih.gov/pubmed/36096674 http://dx.doi.org/10.26508/lsa.202201557 |