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Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of Smad2L
OBJECTIVE: In addition to the carboxy region, Smad2 transcription factor can be phosphorylated in the linker region as well. Phosphorylation of Smad2 linker region (Smad2L) promotes the expression of plasminogen activator inhibitor type 1 (PAI-1) which leads to cardiovascular disorders such as ather...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468725/ https://www.ncbi.nlm.nih.gov/pubmed/36093806 http://dx.doi.org/10.22074/cellj.2022.7720 |