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Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of Smad2L

OBJECTIVE: In addition to the carboxy region, Smad2 transcription factor can be phosphorylated in the linker region as well. Phosphorylation of Smad2 linker region (Smad2L) promotes the expression of plasminogen activator inhibitor type 1 (PAI-1) which leads to cardiovascular disorders such as ather...

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Detalles Bibliográficos
Autores principales:	Hossein, Babaahmadi-Rezaei, Kheirollah, Alireza, Seif, Faezeh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royan Institute 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468725/ https://www.ncbi.nlm.nih.gov/pubmed/36093806 http://dx.doi.org/10.22074/cellj.2022.7720

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