Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery

Diabetes mellitus (DM) promotes colorectal cancer (CRC) carcinogenesis through complex processes and is considered as an independent risk factor for cancer in general and for CRC in particular. Diabetic patients have complications in the postoperative period following CRC surgery. The aim of the pre...

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Autores principales: Popescu, Răzvan Cătălin, Leopa, Nicoleta, Dumitru, Eugen, Mitroi, Anca Florentina, Tocia, Cristina, Dumitru, Andrei, Brînzan, Costel, Botea, Florin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469087/
https://www.ncbi.nlm.nih.gov/pubmed/36160911
http://dx.doi.org/10.3892/etm.2022.11548
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author Popescu, Răzvan Cătălin
Leopa, Nicoleta
Dumitru, Eugen
Mitroi, Anca Florentina
Tocia, Cristina
Dumitru, Andrei
Brînzan, Costel
Botea, Florin
author_facet Popescu, Răzvan Cătălin
Leopa, Nicoleta
Dumitru, Eugen
Mitroi, Anca Florentina
Tocia, Cristina
Dumitru, Andrei
Brînzan, Costel
Botea, Florin
author_sort Popescu, Răzvan Cătălin
collection PubMed
description Diabetes mellitus (DM) promotes colorectal cancer (CRC) carcinogenesis through complex processes and is considered as an independent risk factor for cancer in general and for CRC in particular. Diabetic patients have complications in the postoperative period following CRC surgery. The aim of the present study was to explore the effect of type II DM (T2DM) on postoperative outcomes for CRC compared with non-diabetic patients. The present study analyzed the data from patients admitted to the General Surgery Department, Emergency Hospital of Constanța (Romania) diagnosed with CRC and DM compared with a control group (patients with CRC, without DM, recruited in the same period and frequency matched to cases by number, sex and age) analyzing patient comorbidities and postoperative complications. A total of 61 patients had undergone surgery for CRC and met the inclusion criteria in the present study conducted during September 2020-2021. A total of 30 patients associated T2DM. Diabetic patients have been associated with more comorbidities than non-diabetics; the age-adjusted Charlson comorbidity index score ≥6 was identified in 90% of diabetic patients compared with 45.2% of controls. Grade III Clavien-Dindo classification was observed in 13.3% diabetic patients compared with 3.2% of non-diabetic patients. Additionally, a higher rate of urinary and pulmonary complications (6.7 vs. 3.2% in controls respectively) in patients with diabetes was found. Postoperative hospitalization was prolonged in diabetic patients (P=0.042). Univariate and multivariate analyses revealed that the laparoscopic approach for diabetic patients was found to be associated with <grade III Clavien-Dindo classification (P=0.040) and the absence of surgical site infection (P=0.040). Diabetes predisposes patients to numerous postoperative complications following CRC surgery and postoperative therapeutic conduct must be personalized to prevent possible postoperative complications following CRC.
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spelling pubmed-94690872022-09-24 Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery Popescu, Răzvan Cătălin Leopa, Nicoleta Dumitru, Eugen Mitroi, Anca Florentina Tocia, Cristina Dumitru, Andrei Brînzan, Costel Botea, Florin Exp Ther Med Articles Diabetes mellitus (DM) promotes colorectal cancer (CRC) carcinogenesis through complex processes and is considered as an independent risk factor for cancer in general and for CRC in particular. Diabetic patients have complications in the postoperative period following CRC surgery. The aim of the present study was to explore the effect of type II DM (T2DM) on postoperative outcomes for CRC compared with non-diabetic patients. The present study analyzed the data from patients admitted to the General Surgery Department, Emergency Hospital of Constanța (Romania) diagnosed with CRC and DM compared with a control group (patients with CRC, without DM, recruited in the same period and frequency matched to cases by number, sex and age) analyzing patient comorbidities and postoperative complications. A total of 61 patients had undergone surgery for CRC and met the inclusion criteria in the present study conducted during September 2020-2021. A total of 30 patients associated T2DM. Diabetic patients have been associated with more comorbidities than non-diabetics; the age-adjusted Charlson comorbidity index score ≥6 was identified in 90% of diabetic patients compared with 45.2% of controls. Grade III Clavien-Dindo classification was observed in 13.3% diabetic patients compared with 3.2% of non-diabetic patients. Additionally, a higher rate of urinary and pulmonary complications (6.7 vs. 3.2% in controls respectively) in patients with diabetes was found. Postoperative hospitalization was prolonged in diabetic patients (P=0.042). Univariate and multivariate analyses revealed that the laparoscopic approach for diabetic patients was found to be associated with <grade III Clavien-Dindo classification (P=0.040) and the absence of surgical site infection (P=0.040). Diabetes predisposes patients to numerous postoperative complications following CRC surgery and postoperative therapeutic conduct must be personalized to prevent possible postoperative complications following CRC. D.A. Spandidos 2022-08-02 /pmc/articles/PMC9469087/ /pubmed/36160911 http://dx.doi.org/10.3892/etm.2022.11548 Text en Copyright: © Popescu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Popescu, Răzvan Cătălin
Leopa, Nicoleta
Dumitru, Eugen
Mitroi, Anca Florentina
Tocia, Cristina
Dumitru, Andrei
Brînzan, Costel
Botea, Florin
Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery
title Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery
title_full Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery
title_fullStr Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery
title_full_unstemmed Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery
title_short Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery
title_sort influence of type ii diabetes mellitus on postoperative complications following colorectal cancer surgery
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469087/
https://www.ncbi.nlm.nih.gov/pubmed/36160911
http://dx.doi.org/10.3892/etm.2022.11548
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