GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A(2A) Adenosine Receptor

[Image: see text] Modulators of the G protein-coupled A(2A) adenosine receptor (A(2A)AR) have been considered promising agents to treat Parkinson’s disease, inflammation, cancer, and central nervous system disorders. Herein, we demonstrate that a thiophene modification at the C8 position in the comm...

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Detalles Bibliográficos
Autores principales: Shiriaeva, Anna, Park, Daejin, Kim, Gyudong, Lee, Yoonji, Hou, Xiyan, Jarhad, Dnyandev B., Kim, Gibae, Yu, Jinha, Hyun, Young Eum, Kim, Woomi, Gao, Zhan-Guo, Jacobson, Kenneth A., Han, Gye Won, Stevens, Raymond C., Jeong, Lak Shin, Choi, Sun, Cherezov, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469204/
https://www.ncbi.nlm.nih.gov/pubmed/35977382
http://dx.doi.org/10.1021/acs.jmedchem.2c00462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469204/
https://www.ncbi.nlm.nih.gov/pubmed/35977382
http://dx.doi.org/10.1021/acs.jmedchem.2c00462

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