RHPS4 shifted the conformation ensemble equilibrium of Tel24 by preferentially stabilizing the (3 + 1) hybrid-2 conformation

Telomeric G-quadruplexes have been a promising target for developing antitumor drugs with fewer side effects. The intracellular environment is usually in a state of molecular crowding. Studying the interaction mechanism among ligands and telomeric G-quadruplexes under crowded conditions is important...

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Detalles Bibliográficos
Autores principales: Wang, Zhangqian, Deng, Jieya, Umer, Muhammad, Anwar, Naureen, Wang, Yidang, Dong, XingXing, Xu, Hua, He, Yi, Gao, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469490/
https://www.ncbi.nlm.nih.gov/pubmed/36199604
http://dx.doi.org/10.1039/d2ra03959a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469490/
https://www.ncbi.nlm.nih.gov/pubmed/36199604
http://dx.doi.org/10.1039/d2ra03959a

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