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Novel Design Strategies to Enhance the Efficiency of Proteolysis Targeting Chimeras
[Image: see text] Despite the success of drug discovery over the past decades, many potential drug targets still remain intractable for small molecule modulation. The development of proteolysis targeting chimeras (PROTACs) that trigger degradation of the target proteins provides a conceptually novel...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469497/ https://www.ncbi.nlm.nih.gov/pubmed/36110375 http://dx.doi.org/10.1021/acsptsci.2c00089 |