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CMIC: predicting DNA methylation inheritance of CpG islands with embedding vectors of variable-length k-mers

BACKGROUND: Epigenetic modifications established in mammalian gametes are largely reprogrammed during early development, however, are partly inherited by the embryo to support its development. In this study, we examine CpG island (CGI) sequences to predict whether a mouse blastocyst CGI inherits ooc...

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Detalles Bibliográficos
Autores principales: Maruyama, Osamu, Li, Yinuo, Narita, Hiroki, Toh, Hidehiro, Au Yeung, Wan Kin, Sasaki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469632/
https://www.ncbi.nlm.nih.gov/pubmed/36096737
http://dx.doi.org/10.1186/s12859-022-04916-3