Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug–drug interaction

Physiologically‐based pharmacokinetic (PBPK) models have an important role in drug discovery/development and decision making in regulatory submissions. This is facilitated by predefined PBPK platforms with user‐friendly graphical interface, such as Simcyp and PK‐Sim. However, evaluations of platform...

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Detalles Bibliográficos
Autores principales: Prieto Garcia, Luna, Lundahl, Anna, Ahlström, Christine, Vildhede, Anna, Lennernäs, Hans, Sjögren, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469690/
https://www.ncbi.nlm.nih.gov/pubmed/35722750
http://dx.doi.org/10.1002/psp4.12837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469690/
https://www.ncbi.nlm.nih.gov/pubmed/35722750
http://dx.doi.org/10.1002/psp4.12837

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