Pan-cancer distribution of cleaved cell-surface amphiregulin, the target of the GMF-1A3 antibody drug conjugate

Amphiregulin is a transmembrane protein which, when cleaved by the TACE/ADAM17 protease, releases a soluble epidermal growth factor receptor ligand domain that promotes proliferation of normal and malignant cells. We previously described a rabbit monoclonal antibody, GMF-1A3, that selectively recogn...

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Detalles Bibliográficos
Autores principales: Lofgren, Kristopher A, Reker, Nicolette C, Sreekumar, Sreeja, Kenny, Paraic A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469882/
https://www.ncbi.nlm.nih.gov/pubmed/36110096
http://dx.doi.org/10.1093/abt/tbac020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469882/
https://www.ncbi.nlm.nih.gov/pubmed/36110096
http://dx.doi.org/10.1093/abt/tbac020

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