Rapamycin/metformin co‐treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice

Rapamycin treatment has positive and negative effects on progression of type 2 diabetes (T2D) in a recombinant inbred polygenic mouse model, male NONcNZO10/LtJ (NcZ10). Here, we show that combination treatment with metformin ameliorates negative effects of rapamycin while maintaining its benefits. F...

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Detalles Bibliográficos
Autores principales: Reifsnyder, Peter C., Flurkey, Kevin, Doty, Rosalinda, Calcutt, Nigel A., Koza, Robert A., Harrison, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470898/
https://www.ncbi.nlm.nih.gov/pubmed/35986566
http://dx.doi.org/10.1111/acel.13666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470898/
https://www.ncbi.nlm.nih.gov/pubmed/35986566
http://dx.doi.org/10.1111/acel.13666

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