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Rapamycin/metformin co‐treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice

Rapamycin treatment has positive and negative effects on progression of type 2 diabetes (T2D) in a recombinant inbred polygenic mouse model, male NONcNZO10/LtJ (NcZ10). Here, we show that combination treatment with metformin ameliorates negative effects of rapamycin while maintaining its benefits. F...

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Detalles Bibliográficos
Autores principales:	Reifsnyder, Peter C., Flurkey, Kevin, Doty, Rosalinda, Calcutt, Nigel A., Koza, Robert A., Harrison, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470898/ https://www.ncbi.nlm.nih.gov/pubmed/35986566 http://dx.doi.org/10.1111/acel.13666

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