Mitochondrial uncoupling protein‐2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age‐associated lung fibrosis

Mitochondrial dysfunction has been associated with age‐related diseases, including idiopathic pulmonary fibrosis (IPF). We provide evidence that implicates chronic elevation of the mitochondrial anion carrier protein, uncoupling protein‐2 (UCP2), in increased generation of reactive oxygen species, a...

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Detalles Bibliográficos
Autores principales: Rangarajan, Sunad, Locy, Morgan L., Chanda, Diptiman, Kurundkar, Ashish, Kurundkar, Deepali, Larson‐Casey, Jennifer L., Londono, Pilar, Bagchi, Rushita A., Deskin, Brian, Elajaili, Hanan, Nozik, Eva S., Deshane, Jessy S., Zmijewski, Jaroslaw W., Eickelberg, Oliver, Thannickal, Victor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470902/
https://www.ncbi.nlm.nih.gov/pubmed/35934931
http://dx.doi.org/10.1111/acel.13674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470902/
https://www.ncbi.nlm.nih.gov/pubmed/35934931
http://dx.doi.org/10.1111/acel.13674

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