Premature aging is associated with higher levels of 8‐oxoguanine and increased DNA damage in the Polg mutator mouse

Mitochondrial dysfunction plays an important role in the aging process. However, the mechanism by which this dysfunction causes aging is not fully understood. The accumulation of mutations in the mitochondrial genome (or “mtDNA”) has been proposed as a contributor. One compelling piece of evidence i...

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Detalles Bibliográficos
Autores principales: Yu, Tenghui, Slone, Jesse, Liu, Wensheng, Barnes, Ryan, Opresko, Patricia L., Wark, Landon, Mai, Sabine, Horvath, Steve, Huang, Taosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470903/
https://www.ncbi.nlm.nih.gov/pubmed/35993394
http://dx.doi.org/10.1111/acel.13669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470903/
https://www.ncbi.nlm.nih.gov/pubmed/35993394
http://dx.doi.org/10.1111/acel.13669

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