Personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients

INTRODUCTION: The patterns and clinical correlates related to antidepressant drugs (ADs) prescription for BD remain poorly understood. OBJECTIVES: This study aimed to compare socio-demographic and clinical features of BD patients treated vs. not treated with ADs. METHODS: The sample consists of 287...

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Autores principales: Serafini, G., Vazquez, G., Aguglia, A., Amerio, A., Pompili, M., Amore, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471408/
http://dx.doi.org/10.1192/j.eurpsy.2021.245
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author Serafini, G.
Vazquez, G.
Aguglia, A.
Amerio, A.
Pompili, M.
Amore, M.
author_facet Serafini, G.
Vazquez, G.
Aguglia, A.
Amerio, A.
Pompili, M.
Amore, M.
author_sort Serafini, G.
collection PubMed
description INTRODUCTION: The patterns and clinical correlates related to antidepressant drugs (ADs) prescription for BD remain poorly understood. OBJECTIVES: This study aimed to compare socio-demographic and clinical features of BD patients treated vs. not treated with ADs. METHODS: The sample consists of 287 currently euthymic bipolar patients. Among participants (mean age=51.9±15.02), 157 (40.1%) were receiving ADs. RESULTS: Based on the main findings, subjects given ADs were older and more frequently retired than those without receiving ADs. Moreover, patients given ADs were more likely to have had a first major depressive episode and present with psychotic symptoms at illness onset. Lifetime substance abuse/dependence history was less frequently reported among patients given ADs. Furthermore, ADs given patients have a higher number of affective episodes, and longer duration of their illness. Additionally, subjects treated with ADs reported higher hopelessness levels, and lower positive reinterpretations than those who were not treated with ADs. Factors associated with ADs-use by multivariate modeling were reduced personal autonomy (OR=.070), and hopelessness levels (OR=1.391). CONCLUSIONS: These results may help clinicians to better understand the clinical correlates of BD subtypes and improve their differential management. Additional studies are needed to replicate these findings, and facilitate the differential trajectories of BD patients based on socio-demographic/clinical profile. DISCLOSURE: No significant relationships.
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spelling pubmed-94714082022-09-29 Personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients Serafini, G. Vazquez, G. Aguglia, A. Amerio, A. Pompili, M. Amore, M. Eur Psychiatry Abstract INTRODUCTION: The patterns and clinical correlates related to antidepressant drugs (ADs) prescription for BD remain poorly understood. OBJECTIVES: This study aimed to compare socio-demographic and clinical features of BD patients treated vs. not treated with ADs. METHODS: The sample consists of 287 currently euthymic bipolar patients. Among participants (mean age=51.9±15.02), 157 (40.1%) were receiving ADs. RESULTS: Based on the main findings, subjects given ADs were older and more frequently retired than those without receiving ADs. Moreover, patients given ADs were more likely to have had a first major depressive episode and present with psychotic symptoms at illness onset. Lifetime substance abuse/dependence history was less frequently reported among patients given ADs. Furthermore, ADs given patients have a higher number of affective episodes, and longer duration of their illness. Additionally, subjects treated with ADs reported higher hopelessness levels, and lower positive reinterpretations than those who were not treated with ADs. Factors associated with ADs-use by multivariate modeling were reduced personal autonomy (OR=.070), and hopelessness levels (OR=1.391). CONCLUSIONS: These results may help clinicians to better understand the clinical correlates of BD subtypes and improve their differential management. Additional studies are needed to replicate these findings, and facilitate the differential trajectories of BD patients based on socio-demographic/clinical profile. DISCLOSURE: No significant relationships. Cambridge University Press 2021-08-13 /pmc/articles/PMC9471408/ http://dx.doi.org/10.1192/j.eurpsy.2021.245 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Serafini, G.
Vazquez, G.
Aguglia, A.
Amerio, A.
Pompili, M.
Amore, M.
Personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients
title Personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients
title_full Personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients
title_fullStr Personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients
title_full_unstemmed Personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients
title_short Personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients
title_sort personal autonomy and hopelessness are associated with antidepressant drugs prescription in currently euthymic bipolar patients
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471408/
http://dx.doi.org/10.1192/j.eurpsy.2021.245
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