Transcriptomic signatures responding to PKM2 activator TEPP-46 in the hyperglycemic human renal proximal epithelial tubular cells

Pyruvate kinase M2 (PKM2), as the terminal and last rate-limiting enzyme of the glycolytic pathway, is an ideal enzyme for regulating metabolic phenotype. PKM2 tetramer activation has shown a protective role against diabetic kidney disease (DKD). However, the molecular mechanisms involved in diabeti...

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Detalles Bibliográficos
Autores principales: Wang, Zhimin, Yu, Jiating, Hao, Dan, Liu, Xin, Wang, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471676/
https://www.ncbi.nlm.nih.gov/pubmed/36120453
http://dx.doi.org/10.3389/fendo.2022.965379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471676/
https://www.ncbi.nlm.nih.gov/pubmed/36120453
http://dx.doi.org/10.3389/fendo.2022.965379

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