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Transcriptomic signatures responding to PKM2 activator TEPP-46 in the hyperglycemic human renal proximal epithelial tubular cells

Pyruvate kinase M2 (PKM2), as the terminal and last rate-limiting enzyme of the glycolytic pathway, is an ideal enzyme for regulating metabolic phenotype. PKM2 tetramer activation has shown a protective role against diabetic kidney disease (DKD). However, the molecular mechanisms involved in diabeti...

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Detalles Bibliográficos
Autores principales:	Wang, Zhimin, Yu, Jiating, Hao, Dan, Liu, Xin, Wang, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471676/ https://www.ncbi.nlm.nih.gov/pubmed/36120453 http://dx.doi.org/10.3389/fendo.2022.965379

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