Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression

Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) proteins. Overexpression and unordered organization of ECM proteins cause tissue fibrosis in damaged tissue. Fi...

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Detalles Bibliográficos
Autores principales: Sun, Changye, Tian, Xiangqin, Jia, Yangyang, Yang, Mingming, Li, Yong, Fernig, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471990/
https://www.ncbi.nlm.nih.gov/pubmed/36102060
http://dx.doi.org/10.1098/rsob.210356
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author Sun, Changye
Tian, Xiangqin
Jia, Yangyang
Yang, Mingming
Li, Yong
Fernig, David G.
author_facet Sun, Changye
Tian, Xiangqin
Jia, Yangyang
Yang, Mingming
Li, Yong
Fernig, David G.
author_sort Sun, Changye
collection PubMed
description Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) proteins. Overexpression and unordered organization of ECM proteins cause tissue fibrosis in damaged tissue. Fibroblast growth factor (FGF) family proteins are well known to promote angiogenesis and tissue repair, but their activities in fibroblast differentiation and fibrosis have not been systematically reviewed. Here we summarize the effects of FGFs in fibroblast to myofibroblast differentiation and ECM protein expression and discuss the underlying potential regulatory mechanisms, to provide a basis for the clinical application of recombinant FGF protein drugs in treatment of tissue damage.
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spelling pubmed-94719902022-09-19 Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression Sun, Changye Tian, Xiangqin Jia, Yangyang Yang, Mingming Li, Yong Fernig, David G. Open Biol Review Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) proteins. Overexpression and unordered organization of ECM proteins cause tissue fibrosis in damaged tissue. Fibroblast growth factor (FGF) family proteins are well known to promote angiogenesis and tissue repair, but their activities in fibroblast differentiation and fibrosis have not been systematically reviewed. Here we summarize the effects of FGFs in fibroblast to myofibroblast differentiation and ECM protein expression and discuss the underlying potential regulatory mechanisms, to provide a basis for the clinical application of recombinant FGF protein drugs in treatment of tissue damage. The Royal Society 2022-09-14 /pmc/articles/PMC9471990/ /pubmed/36102060 http://dx.doi.org/10.1098/rsob.210356 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Sun, Changye
Tian, Xiangqin
Jia, Yangyang
Yang, Mingming
Li, Yong
Fernig, David G.
Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
title Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
title_full Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
title_fullStr Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
title_full_unstemmed Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
title_short Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
title_sort functions of exogenous fgf signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471990/
https://www.ncbi.nlm.nih.gov/pubmed/36102060
http://dx.doi.org/10.1098/rsob.210356
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