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Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study

INTRODUCTION: This prospective pharmacodynamic nutraceutical study assessed the effect of a 1-week trial of 30 g/day of 65% cocoa (dark chocolate) (Theobroma cacao L.) consumption intervention on platelet reactivity. METHODS: Patients with stable coronary artery disease (CAD) (n=20) who were on main...

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Autores principales: Seecheran, Naveen Anand, Sukha, Darin, Grimaldos, Kathryn, Grimaldos, Gabriella, Richard, Srivane, Ishmael, Aleena, Gomes, Ceylon, Kampradi, Lirmala, Seecheran, Rajeev, Seecheran, Valmiki, Peram, Lakshmipathi, Dookeeram, Darren, Giddings, Stanley, Sandy, Sherry, Ramlackhansingh, Anil, Raza, Sadi, Umaharan, Pathmanathan, Tello-Montoliu, Antonio, Schneider, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472200/
https://www.ncbi.nlm.nih.gov/pubmed/36100318
http://dx.doi.org/10.1136/openhrt-2022-002066
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author Seecheran, Naveen Anand
Sukha, Darin
Grimaldos, Kathryn
Grimaldos, Gabriella
Richard, Srivane
Ishmael, Aleena
Gomes, Ceylon
Kampradi, Lirmala
Seecheran, Rajeev
Seecheran, Valmiki
Peram, Lakshmipathi
Dookeeram, Darren
Giddings, Stanley
Sandy, Sherry
Ramlackhansingh, Anil
Raza, Sadi
Umaharan, Pathmanathan
Tello-Montoliu, Antonio
Schneider, David
author_facet Seecheran, Naveen Anand
Sukha, Darin
Grimaldos, Kathryn
Grimaldos, Gabriella
Richard, Srivane
Ishmael, Aleena
Gomes, Ceylon
Kampradi, Lirmala
Seecheran, Rajeev
Seecheran, Valmiki
Peram, Lakshmipathi
Dookeeram, Darren
Giddings, Stanley
Sandy, Sherry
Ramlackhansingh, Anil
Raza, Sadi
Umaharan, Pathmanathan
Tello-Montoliu, Antonio
Schneider, David
author_sort Seecheran, Naveen Anand
collection PubMed
description INTRODUCTION: This prospective pharmacodynamic nutraceutical study assessed the effect of a 1-week trial of 30 g/day of 65% cocoa (dark chocolate) (Theobroma cacao L.) consumption intervention on platelet reactivity. METHODS: Patients with stable coronary artery disease (CAD) (n=20) who were on maintenance dual antiplatelet therapy of aspirin (ASA) 81 mg/day and clopidogrel 75 mg/day were recruited. Platelet function was evaluated with the VerifyNow P2Y(12) reaction unit (PRU) and aspirin reaction unit (ARU) assays (Werfen, Bedford, Massachusetts, USA) and assessed prior to initiation of and after a 1-week trial of 30 g/day of 65% cocoa consumption intervention. Results were compared with a paired t-test. RESULTS: Cocoa augmented the inhibitory effect of clopidogrel, demonstrated by a reduction of 11.9% (95% CI 5.7% to 18.0%, p value 0.001), significantly decreasing the PRU by 26.85 (95% CI 12.22 to 41.48, p value 0.001). The inhibitory effect of ASA was not impacted by cocoa, reflected by a non-significant reduction in ARU of 17.65 (95% CI 21.00 to 56.3, p value 0.351). No patients experienced any serious adverse events. CONCLUSIONS: Cocoa augmented the inhibitory effect of clopidogrel but not ASA. This nutraceutical study could be potentially informative and applicable for patients with stable CAD. Further long-term studies are required to confirm these exploratory findings. TRIAL REGISTRATION NUMBER: NCT04554901.
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spelling pubmed-94722002022-09-15 Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study Seecheran, Naveen Anand Sukha, Darin Grimaldos, Kathryn Grimaldos, Gabriella Richard, Srivane Ishmael, Aleena Gomes, Ceylon Kampradi, Lirmala Seecheran, Rajeev Seecheran, Valmiki Peram, Lakshmipathi Dookeeram, Darren Giddings, Stanley Sandy, Sherry Ramlackhansingh, Anil Raza, Sadi Umaharan, Pathmanathan Tello-Montoliu, Antonio Schneider, David Open Heart Coronary Artery Disease INTRODUCTION: This prospective pharmacodynamic nutraceutical study assessed the effect of a 1-week trial of 30 g/day of 65% cocoa (dark chocolate) (Theobroma cacao L.) consumption intervention on platelet reactivity. METHODS: Patients with stable coronary artery disease (CAD) (n=20) who were on maintenance dual antiplatelet therapy of aspirin (ASA) 81 mg/day and clopidogrel 75 mg/day were recruited. Platelet function was evaluated with the VerifyNow P2Y(12) reaction unit (PRU) and aspirin reaction unit (ARU) assays (Werfen, Bedford, Massachusetts, USA) and assessed prior to initiation of and after a 1-week trial of 30 g/day of 65% cocoa consumption intervention. Results were compared with a paired t-test. RESULTS: Cocoa augmented the inhibitory effect of clopidogrel, demonstrated by a reduction of 11.9% (95% CI 5.7% to 18.0%, p value 0.001), significantly decreasing the PRU by 26.85 (95% CI 12.22 to 41.48, p value 0.001). The inhibitory effect of ASA was not impacted by cocoa, reflected by a non-significant reduction in ARU of 17.65 (95% CI 21.00 to 56.3, p value 0.351). No patients experienced any serious adverse events. CONCLUSIONS: Cocoa augmented the inhibitory effect of clopidogrel but not ASA. This nutraceutical study could be potentially informative and applicable for patients with stable CAD. Further long-term studies are required to confirm these exploratory findings. TRIAL REGISTRATION NUMBER: NCT04554901. BMJ Publishing Group 2022-09-13 /pmc/articles/PMC9472200/ /pubmed/36100318 http://dx.doi.org/10.1136/openhrt-2022-002066 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Coronary Artery Disease
Seecheran, Naveen Anand
Sukha, Darin
Grimaldos, Kathryn
Grimaldos, Gabriella
Richard, Srivane
Ishmael, Aleena
Gomes, Ceylon
Kampradi, Lirmala
Seecheran, Rajeev
Seecheran, Valmiki
Peram, Lakshmipathi
Dookeeram, Darren
Giddings, Stanley
Sandy, Sherry
Ramlackhansingh, Anil
Raza, Sadi
Umaharan, Pathmanathan
Tello-Montoliu, Antonio
Schneider, David
Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study
title Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study
title_full Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study
title_fullStr Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study
title_full_unstemmed Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study
title_short Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study
title_sort effect of cocoa (theobroma cacao l.) on platelet function testing profiles in patients with coronary artery disease: eclair pilot study
topic Coronary Artery Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472200/
https://www.ncbi.nlm.nih.gov/pubmed/36100318
http://dx.doi.org/10.1136/openhrt-2022-002066
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