Predicting Total Drug Clearance and Volumes of Distribution Using the Machine Learning-Mediated Multimodal Method through the Imputation of Various Nonclinical Data

[Image: see text] Pharmacokinetic research plays an important role in the development of new drugs. Accurate predictions of human pharmacokinetic parameters are essential for the success of clinical trials. Clearance (CL) and volume of distribution (Vd) are important factors for evaluating pharmacok...

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Detalles Bibliográficos
Autores principales: Iwata, Hiroaki, Matsuo, Tatsuru, Mamada, Hideaki, Motomura, Takahisa, Matsushita, Mayumi, Fujiwara, Takeshi, Maeda, Kazuya, Handa, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472274/
https://www.ncbi.nlm.nih.gov/pubmed/35993595
http://dx.doi.org/10.1021/acs.jcim.2c00318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472274/
https://www.ncbi.nlm.nih.gov/pubmed/35993595
http://dx.doi.org/10.1021/acs.jcim.2c00318

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