QM/MM Well-Tempered Metadynamics Study of the Mechanism of XBP1 mRNA Cleavage by Inositol Requiring Enzyme 1α RNase

[Image: see text] A range of in silico methodologies were herein employed to study the unconventional XBP1 mRNA cleavage mechanism performed by the unfolded protein response (UPR) mediator Inositol Requiring Enzyme 1α (IRE1). Using Protein–RNA molecular docking along with a series of extensive restr...

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Detalles Bibliográficos
Autores principales: Mahdizadeh, Sayyed Jalil, Pålsson, Emil, Carlesso, Antonio, Chevet, Eric, Eriksson, Leif A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472280/
https://www.ncbi.nlm.nih.gov/pubmed/35960929
http://dx.doi.org/10.1021/acs.jcim.2c00735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472280/
https://www.ncbi.nlm.nih.gov/pubmed/35960929
http://dx.doi.org/10.1021/acs.jcim.2c00735

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