Reversing BCG-mediated autophagy inhibition and mycobacterial survival to improve vaccine efficacy

BACKGROUND: Autophagy is an important mechanism for promoting Mycobacterium clearance from macrophages. Pathogenic and non-pathogenic mycobacterium can activate the mTOR pathway while simultaneously inducing autophagy. M. tuberculosis and M. bovis BCG inhibit autophagy and favor intracellular bacter...

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Detalles Bibliográficos
Autores principales: Gonzalez-Orozco, Maria, Strong, Emily J., Paroha, Ruchi, Lee, Sunhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472362/
https://www.ncbi.nlm.nih.gov/pubmed/36104771
http://dx.doi.org/10.1186/s12865-022-00518-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472362/
https://www.ncbi.nlm.nih.gov/pubmed/36104771
http://dx.doi.org/10.1186/s12865-022-00518-z

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