ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain

Patients with human epidermal growth factor receptor 2-positive (HER2+/ERBB2) breast cancer often present with brain metastasis. HER2-targeted therapies have not been successful to treat brain metastases in part due to poor blood-brain barrier (BBB) penetrance and emergence of resistance. Here, we r...

Descripción completa

Detalles Bibliográficos
Autores principales: McKernan, Courtney M., Khatri, Aaditya, Hannigan, Molly, Child, Jessica, Chen, Qiang, Mayro, Benjamin, Snyder, David, Nicchitta, Christopher V., Pendergast, Ann Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472557/
https://www.ncbi.nlm.nih.gov/pubmed/36044842
http://dx.doi.org/10.1016/j.celrep.2022.111268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472557/
https://www.ncbi.nlm.nih.gov/pubmed/36044842
http://dx.doi.org/10.1016/j.celrep.2022.111268

Ejemplares similares