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ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain

Patients with human epidermal growth factor receptor 2-positive (HER2+/ERBB2) breast cancer often present with brain metastasis. HER2-targeted therapies have not been successful to treat brain metastases in part due to poor blood-brain barrier (BBB) penetrance and emergence of resistance. Here, we r...

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Detalles Bibliográficos
Autores principales:	McKernan, Courtney M., Khatri, Aaditya, Hannigan, Molly, Child, Jessica, Chen, Qiang, Mayro, Benjamin, Snyder, David, Nicchitta, Christopher V., Pendergast, Ann Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472557/ https://www.ncbi.nlm.nih.gov/pubmed/36044842 http://dx.doi.org/10.1016/j.celrep.2022.111268

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