Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection

Humoral immune perturbations contribute to pathogenic outcomes in persons with HIV-1 infection (PWH). Gut barrier dysfunction in PWH is associated with microbial translocation and alterations in microbial communities (dysbiosis), and IgA, the most abundant immunoglobulin (Ig) isotype in the gut, is...

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Detalles Bibliográficos
Autores principales: Jones, Sean T., Guo, Kejun, Cooper, Emily H., Dillon, Stephanie M., Wood, Cheyret, Nguyen, David H., Shen, Guannan, Barrett, Bradley S., Frank, Daniel N., Kroehl, Miranda, Janoff, Edward N., Kechris, Katerina, Wilson, Cara C., Santiago, Mario L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472609/
https://www.ncbi.nlm.nih.gov/pubmed/35938870
http://dx.doi.org/10.1128/jvi.00976-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472609/
https://www.ncbi.nlm.nih.gov/pubmed/35938870
http://dx.doi.org/10.1128/jvi.00976-22

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