Modern Solutions for Ancient Pathogens: Direct Pathogen Sequencing for Diagnosis of Lepromatous Leprosy and Cerebral Coenurosis

Microbes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pat...

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Detalles Bibliográficos
Autores principales: Young, Bernadette C, Bush, Stephen J, Lipworth, Sam, George, Sophie, Dingle, Kate E, Sanderson, Nick, Brankin, Alice, Walker, Timothy, Sharma, Srilakshmi, Leong, James, Plaha, Puneet, Hofer, Monika, Chiodini, Peter, Gottstein, B, Furrer, Lavinia, Crook, Derrick, Brent, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472670/
https://www.ncbi.nlm.nih.gov/pubmed/36119959
http://dx.doi.org/10.1093/ofid/ofac428
Descripción
Sumario:Microbes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pathogen DNA sequencing provides flexible solutions to diagnosis of difficult pathogens in diverse contexts.

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