Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth

IDO1 is an immunomodulatory enzyme responsible for tryptophan catabolism. Its expression in immune cells, especially the DCs, has attracted attention because it leads to tryptophan depletion at the immunological synapse, thereby causing T-cell anergy and immune evasion by the tumor cells. Cancer cel...

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Detalles Bibliográficos
Autores principales: Korac, Ksenija, Rajasekaran, Devaraja, Sniegowski, Tyler, Schniers, Bradley K., Ibrahim, Andrew F., Bhutia, Yangzom D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472820/
https://www.ncbi.nlm.nih.gov/pubmed/35997090
http://dx.doi.org/10.1042/BCJ20210851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472820/
https://www.ncbi.nlm.nih.gov/pubmed/35997090
http://dx.doi.org/10.1042/BCJ20210851

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