Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity are being tested in clinical trials. Numerous rare variants of unknown clinical significance have been reported, but how the vast majori...

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Detalles Bibliográficos
Autores principales: Kalogeropulou, Alexia F., Purlyte, Elena, Tonelli, Francesca, Lange, Sven M., Wightman, Melanie, Prescott, Alan R., Padmanabhan, Shalini, Sammler, Esther, Alessi, Dario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472821/
https://www.ncbi.nlm.nih.gov/pubmed/35950872
http://dx.doi.org/10.1042/BCJ20220161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472821/
https://www.ncbi.nlm.nih.gov/pubmed/35950872
http://dx.doi.org/10.1042/BCJ20220161

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