Clearance of variant Creutzfeldt–Jakob disease prions in vivo by the Hsp70 disaggregase system

The metazoan Hsp70 disaggregase protects neurons from proteotoxicity that arises from the accumulation of misfolded protein aggregates. Hsp70 and its co-chaperones disassemble and extract polypeptides from protein aggregates for refolding or degradation. The effectiveness of the chaperone system dec...

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Detalles Bibliográficos
Autores principales: Thackray, Alana M, Lam, Brian, McNulty, Erin E, Nalls, Amy V, Mathiason, Candace K, Magadi, Srivathsa Subramanya, Jackson, Walker S, Andréoletti, Olivier, Marrero-Winkens, Cristóbal, Schätzl, Hermann, Bujdoso, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473358/
https://www.ncbi.nlm.nih.gov/pubmed/35446941
http://dx.doi.org/10.1093/brain/awac144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473358/
https://www.ncbi.nlm.nih.gov/pubmed/35446941
http://dx.doi.org/10.1093/brain/awac144

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