Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease

Huntington's disease is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in ageing humans. To address this, we generated induced neurons t...

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Detalles Bibliográficos
Autores principales: Pircs, Karolina, Drouin-Ouellet, Janelle, Horváth, Vivien, Gil, Jeovanis, Rezeli, Melinda, Garza, Raquel, Grassi, Daniela A, Sharma, Yogita, St-Amour, Isabelle, Harris, Kate, Jönsson, Marie E, Johansson, Pia A, Vuono, Romina, Fazal, Shaline V, Stoker, Thomas, Hersbach, Bob A, Sharma, Kritika, Lagerwall, Jessica, Lagerström, Stina, Storm, Petter, Hébert, Sébastien S, Marko-Varga, György, Parmar, Malin, Barker, Roger A, Jakobsson, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473361/
https://www.ncbi.nlm.nih.gov/pubmed/34936701
http://dx.doi.org/10.1093/brain/awab473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473361/
https://www.ncbi.nlm.nih.gov/pubmed/34936701
http://dx.doi.org/10.1093/brain/awab473

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