A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4(+) T-cell immunity

Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II endosomal pathway and elicit CD4(+) T cells. We developed a new generation of LVs encoding antigen-bearing monomers of collectins substituted at their C-terminal domain with the...

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Detalles Bibliográficos
Autores principales: Anna, François, Lopez, Jodie, Moncoq, Fanny, Blanc, Catherine, Authié, Pierre, Noirat, Amandine, Fert, Ingrid, Souque, Philippe, Nevo, Fabien, Pawlik, Alexandre, Hardy, David, Goyard, Sophie, Hudrisier, Denis, Brosch, Roland, Guinet, Françoise, Neyrolles, Olivier, Charneau, Pierre, Majlessi, Laleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473479/
https://www.ncbi.nlm.nih.gov/pubmed/36104497
http://dx.doi.org/10.1038/s41385-022-00566-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473479/
https://www.ncbi.nlm.nih.gov/pubmed/36104497
http://dx.doi.org/10.1038/s41385-022-00566-z

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