Topologically switchable and gated transcription machinery

Topological barriers control in nature the transcription machinery, thereby perturbing gene expression. Here we introduce synthetically designed DNA templates that include built-in topological barriers for switchable, triggered-controlled transcription of RNA aptamers. This is exemplified with the d...

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Detalles Bibliográficos
Autores principales: Zhang, Pu, Fischer, Amit, Ouyang, Yu, Sohn, Yang Sung, Nechushtai, Rachel, Zhang, Junji, Tian, He, Fan, Chunhai, Willner, Itamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473513/
https://www.ncbi.nlm.nih.gov/pubmed/36277654
http://dx.doi.org/10.1039/d2sc01599d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473513/
https://www.ncbi.nlm.nih.gov/pubmed/36277654
http://dx.doi.org/10.1039/d2sc01599d

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