Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation

The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and catabolism in response to nutrients through phosphorylation of key substrates. The tumor suppressor folliculin (FLCN) is a RagC/D guanosine triphosphatase (GTPase)–activating protein (GAP) that regulates mTORC1 phosphor...

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Detalles Bibliográficos
Autores principales: Jansen, Rachel M., Peruzzo, Roberta, Fromm, Simon A., Yokom, Adam L., Zoncu, Roberto, Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473554/
https://www.ncbi.nlm.nih.gov/pubmed/36103527
http://dx.doi.org/10.1126/sciadv.add2926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473554/
https://www.ncbi.nlm.nih.gov/pubmed/36103527
http://dx.doi.org/10.1126/sciadv.add2926

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