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Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation

The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and catabolism in response to nutrients through phosphorylation of key substrates. The tumor suppressor folliculin (FLCN) is a RagC/D guanosine triphosphatase (GTPase)–activating protein (GAP) that regulates mTORC1 phosphor...

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Detalles Bibliográficos
Autores principales:	Jansen, Rachel M., Peruzzo, Roberta, Fromm, Simon A., Yokom, Adam L., Zoncu, Roberto, Hurley, James H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473554/ https://www.ncbi.nlm.nih.gov/pubmed/36103527 http://dx.doi.org/10.1126/sciadv.add2926

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