Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells

IFNα is a key regulator of the dialogue between pancreatic β cells and the immune system in early type 1 diabetes (T1D). IFNα up-regulates HLA class I expression in human β cells, fostering autoantigen presentation to the immune system. We observed by bulk and single-cell RNA sequencing that exposur...

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Detalles Bibliográficos
Autores principales: Szymczak, Florian, Alvelos, Maria Inês, Marín-Cañas, Sandra, Castela, Ângela, Demine, Stéphane, Colli, Maikel Luis, Op de Beeck, Anne, Thomaidou, Sofia, Marselli, Lorella, Zaldumbide, Arnaud, Marchetti, Piero, Eizirik, Décio L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473574/
https://www.ncbi.nlm.nih.gov/pubmed/36103539
http://dx.doi.org/10.1126/sciadv.abn5732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473574/
https://www.ncbi.nlm.nih.gov/pubmed/36103539
http://dx.doi.org/10.1126/sciadv.abn5732

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