Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases

CRISPR-Cas9 gene editing has emerged as a powerful therapeutic technology, but the lack of safe and efficient in vivo delivery systems, especially for tissue-specific vectors, limits its broad clinical applications. Delivery of Cas9 ribonucleoprotein (RNP) owns competitive advantages over other opti...

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Detalles Bibliográficos
Autores principales: Wan, Tao, Zhong, Jiafeng, Pan, Qi, Zhou, Tianhua, Ping, Yuan, Liu, Xiangrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473578/
https://www.ncbi.nlm.nih.gov/pubmed/36103526
http://dx.doi.org/10.1126/sciadv.abp9435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473578/
https://www.ncbi.nlm.nih.gov/pubmed/36103526
http://dx.doi.org/10.1126/sciadv.abp9435

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